Human Hepatocytes

SKU A-HUCPI Category
This item is perishable and is shipped on ice via expedited shipping
This item cannot be shipped outside of the United States

$1,195.00

vial(s)

Clinically relevant drug-drug interactions (DDI) are a serious concern for any new drug development project. To better support capturing the multiple mechanisms of DDI potential using primary hepatocytes, we now offer Interaction Qualified Human Hepatocytes (Catalog HUCPI) which are characterized for 3 major mechanisms of DDI: transporter activity, enzyme activity, and induction potential, providing you with one product to meet more of your hepatocyte DDI study needs.

Benefits:

  • Use the same donor for basal clearance, transport, and induction studies

  • Actual rates of transport reported rather than relative rates for less ambiguity

  • Large lots mean fewer rounds of testing so you can focus on results

  • Prequalified in Lonza media for better reproducibility

Features:

  • Inducibility of enzyme activity for CYP3A4, CYP2B6, and CYP1A2

  • Inducibility of mRNA for CYP3A4, CYP2B6, CYP1A2, and CYP2C8 genes

  • Actual rate of uptake or efflux for OATP1B1/3, OCT1/2, NTCP, and BSEP** transporters

  • Differences in passive vs. active uptake for OATP1B1/3, OCT1/2, and NTCP transporters.

  • Basal metabolism for 8 CYPs, SULT, UGT, and aldehyde oxidase

  • Plated low-turnover clearance for CYP2C9, CYP2D6, and CYP3A4

  • Complementary thawing, plating, and maintenance medium available

  • > 5 million viable cells/vial

Applications:

  • Drug-Drug interaction studies

  • Low clearance metabolism studies

  • Drug uptake and efflux

  • Disease modeling

  • Xenotransplantation

  • Short term cellular toxicity studies

  • 3D bioprinted models in GelMA, Lifeink® 200, PureCol®, PhotoCol®, PhotoHA®

Safety Data Sheet

Our qualification methods are modeled after recommendations from the FDA publication In Vitro Metabolism and Transporter Mediated Drug-Drug Interaction Studies Guidance for Industry (2017, http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm).

***BSEP efflux activity is measured using the method described in Jie Zhang, et al., Chemico-Biological Interactions, Volume 255, 2016, Pages 45-54

Details

Weight 0.1 lbs
Dimensions 1 × 1 × 1 in
Contents

Sterile, cryopreserved vial containing >5 million cells

Storage

-130˚ C

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