Allevi Blog

Bioprinting with Corning Matrigel Matrix

bioprinting Corning matrigel on Allevi bioprinter

After 30 years of discoveries and over 10,000 citations, Corning® Matrigel® matrix has cemented its place as a trusted ECM in labs worldwide. Biologists, tissue engineers, and industry giants alike rely on Matrigel matrix as a foundational biomaterial for diverse applications; from cancer and stem cell research to neurobiology.

At Allevi, we strive to make 3D bioprinters that are capable of printing high-quality bioinks; without the need for viscosity agents that can hinder your ECM’s performance. We engineered our patented CORE printheads to optimally print pure biomaterials, such as Matrigel matrix, so you can continue working with the bioinks that you already know and trust. We’re excited to announce that we recently worked with Corning Life Sciences to develop the first-ever protocol for bioprinting using Matrigel matrix.

Matrigel matrix, produced by Corning, is a natural ECM-based hydrogel derived from Engelbreth-Holm-Swarm (EHS) mouse sarcoma. This bioink is rich in ECM proteins such as laminin, collagen IV, heparan sulfate proteoglycans, entactin/nidogen, and a number of growth factors. This network of proteins provides the environment needed for optimal tissue performance, driving cellular responses such as proliferation and attachment.

This is why we are pleased to add the Allevi bioprinting protocol using Matrigel matrix to your bioprinting arsenal. Matrigel matrix has a unique formulation that when used with Allevi bioprinters allow you to create custom 3D tissues. This is an optimal platform for cells to differentiate and behave more closely to how they would in the human body. We can’t wait to see what you will do when you bioprint with Allevi and Matrigel matrix in your lab. It’s been 30 years of breakthroughs with Matrigel matrix, and we have a feeling that the pace of discovery is bound to quicken as we add another dimension to this bioink.

Read the full protocol here.

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