The strength of the extracellular matrix (ECM) is that it is hierarchical in terms of matrix built-up, matrix density and fiber structure, which allows for hormones, cytokines, and other small
The rapid and tailored biofabrication of natural materials is of high interest for the field of tissue engineering and regenerative medicine. Scaffolds require both high biocompatibility and tissue-dependent mechanical strength
Poly(vinyl alcohol) cryogel (PVA) is a versatile biomaterial used to replicate the biomechanics of tissues. Additive manufacture (AM) at sub-zero (°C) temperatures enables the manufacture of PVA with complex geometry;
Structural recapitulation is one of the prime prerequisites for the biomechanics of a complex tissue like annulus fibrosus (AF). Design and fabrication of a biomimetic AF anatomical structure has garnered
Scaffolds are implants used to accelerate bone regeneration process, being a relevant element of research in bone tissue engineering field. In this context, the proposal of this research was to
Biophysical cues in the extracellular matrix (ECM) regulate cell behavior in a complex, nonlinear, and interdependent manner. To quantify these important regulatory relationships and gain a comprehensive understanding of mechanotransduction,
Engineered 3-D tissues that replicate composite in vivo architectures have shown great potential for use in biomedical research. Cell-encapsulated hydrogel microscaffolds have been applied widely as basic building blocks to
We report the use of phenolic functional groups of lignosulfonate to impart antioxidant properties and the cell binding domains of gelatin to enhance cell adhesion for poly(ethylene glycol) (PEG)-based scaffolds.
Copper contamination of drinking water and marine areas is detrimental to human health and the environment. Physical and chemical approaches currently used for copper removal from water tend to be
The natural extracellular matrix (ECM)within tissues isphysically contracted and remodeled by cells, allowingthe collective shaping offunctional tissue architectures. Synthetic materials that facilitateself-assembly similar to natural ECM are neededfor cell culture,
Drug-eluting bandage contact lenses (BCLs) have been widely studied as an alternative to eye drops due to their ability to increase the drug residence time and bioavailability as well as
In vitro three-dimensional (3D) cellular models with native tissue-like architectures and functions have potential as alternatives to human tissues in regenerative medicine and drug discovery. However, it is difficult to
